How Trulance works

Trulance replicates what bodies may do naturally*

Trulance is the only medication for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) that is nearly identical to uroguanylin,† a peptide (building block of protein) that occurs naturally in your body. To best understand how uroguanylin works, let’s take a closer look at what happens in your body during the process of digestion.

  • After you eat, food is broken down in the stomach and the intestines
  • In the digestion process, fluid helps to form the consistency of the stool created from the waste that’s left behind
  • When there is too little fluid, it may result in constipation, while too much may result in diarrhea
  • Uroguanylin works best in the small intestine, where—based on the changing pH levels—it provides the right amount of fluid to create well-formed stool*
Interested in learning more?WATCH THE PROCESS >

Uroguanylin has also been shown to reduce abdominal pain*

*This activity was seen in animal studies. The relevance to humans is not yet known. †Pronounced “yur-oh-gwah-nih-lin.”

How do Trulance and uroguanylin differ?

Trulance is very similar to naturally occurring uroguanylin, with exception of a single small molecular difference that improves how Trulance attaches in the small intestine.

Where in the body does Trulance work?

Trulance is thought to work primarily in the small intestine.*

*This activity was seen in animal studies. The relevance to humans is not yet known.

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What Is Trulance?

Trulance® (plecanatide) 3 mg tablets is a prescription medicine used in adults to treat Irritable Bowel Syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC). Chronic means the constipation is long lasting. “Idiopathic” means the cause of the constipation is unknown. It is not known if Trulance is safe and effective in children less than 18 years of age.

What is the most important information I should know about Trulance?

  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).

What Is Trulance?

What is the most important information I should know about Trulance?

  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).
See Less

What Is Trulance?

Trulance® (plecanatide) 3 mg tablets is a prescription medicine used in adults to treat Irritable Bowel Syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC). Chronic means the constipation is long lasting. “Idiopathic” means the cause of the constipation is unknown. It is not known if Trulance is safe and effective in children less than 18 years of age.

What is the most important information I should know about Trulance?

  • Do not give Trulance to children who are less than 6 years of age. It may harm them.
  • You should not give Trulance to children 6 years to less than 18 years of age. It may harm them.
  • Do not take Trulance if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take Trulance, tell your doctor:

  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if Trulance will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if Trulance passes into your breast milk. Talk with your doctor about the best way to feed your baby if you take Trulance.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the common side effects of Trulance?

Diarrhea is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 4 weeks of Trulance treatment. Stop taking Trulance and call your doctor right away if you get severe diarrhea.

These are not all the possible side effects of Trulance. Call your doctor for medical advice about side effects.

You are encouraged to report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center

Phone: 1-800-321-4576

Fax: 1-510-595-8183

Please click here for full Prescribing Information for Trulance, including Medication Guide and BOXED WARNING.

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